(http://www.jbc.org/content/206/2/511.citation)Tj endobj 450 0 obj <> ACKNOWLEDGEMENTS The se last p ages of a PhD thesis a re usually the most widely re ad pages of the entire publication. 461 0 obj endobj endobj Cell Reports Report GRP94 Regulates Circulating Cholesterol Levels through Blockade of PCSK9-Induced LDLR Degradation Steve Poirier,1,2 Maya Mamarbachi,1 Wan-Ting Chen,3 Amy S. Lee,3 and Gaetan Mayer1,2,4,* 1Laboratory of Molecular Cell Biology, Montreal Heart Institute, Montre´al, QC H1T 1C8, Canada 2Department of Pharmacology, Faculty of Medicine, Universite ´de Montreal, Montreal, QC … (Christian B. Anfinsen)Tj -0.66701 1 Td 216 0 obj ET 224 0 obj <> endobj endobj 462 0 obj Examination of cholesterol utilization dur-ing mycobacterial growth using the coupled cholesterol- <> 4.44499 1 Td /T1_0 1 Tf endobj endobj uuid:f2996e4f-1dd1-11b2-0a00-bf0000000000 ET 536 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> T* <> T* <> 210 0 obj f �-��2DaV:���`P�pt�|5[&�ޟ���' ~��%.�_�� T�� /=�M�j1 Nֺ���^Ž\���K���a��c�-A�W Ae�5W�2�,V�����W!A�k�ʐA�z���ǖ��0D���T, Cholesterol-Mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis. ՝/�I��QI������`��n�.��&���[b��\b]���OB^�6��ۙB4��m��������S�Q$�jWP�w&��[�~t��S�o? (When a correction for this article is posted)Tj <> endobj 464 0 obj Maximum cholesterol degradation by the isolates occurred in the cholesterol medium (Medium-A), where cholesterol (1 g/L) was supplemented with as a sole carbon source for 6 d. Approx, 65-80% of the cholesterol was degraded by the isolates (Table 2). The isolated microorganisms were grown in the 0 g [250 0 R 251 0 R 252 0 R 253 0 R 254 0 R 255 0 R 256 0 R 257 0 R 258 0 R] 0 g [268 0 R 269 0 R 270 0 R 271 0 R 272 0 R 273 0 R 274 0 R] %PDF-1.5 %���� -19.67698 0 Td <> We present in this study the potential of Gordonia cholesterolivorans to use cholesterol as the only car-bon and energy source for … endobj 451 0 obj 473 0 obj <> ( by guest on December 27, 2020)Tj <> 203 0 obj 398 0 obj ( to choose from all of JBC's e-mail)Tj 503 0 obj <> /T1_3 1 Tf <>stream The formation and further degradation of SOPs was also analyzed by GC-MS. 3 0 obj 466 0 obj endobj 486 0 obj In these preparations cholesterol degradation was further enhanced by\ud growth of R. equi No. 312 468 l endobj [443 0 R 444 0 R 445 0 R 446 0 R 237 0 R] (STUDIES ON THE MICROBIOLOGICAL)Tj (Access the most updated version of this article at )Tj 496 0 obj In this report, our objective was to develop an integral mathematic model for studying the thermal degradation or oxidation of quercetin in the presence and absence of cholesterol. endobj [307 0 R 308 0 R 309 0 R 310 0 R 311 0 R 312 0 R 313 0 R 314 0 R 315 0 R 316 0 R 317 0 R 318 0 R 319 0 R 320 0 R] 213 0 obj <>/ProcSet[/PDF/Text]>>/Type/Page>> 468 0 obj endobj 348 0 obj 89 468 m endobj [492 0 R 493 0 R 494 0 R 495 0 R 496 0 R 497 0 R 498 0 R] endstream endobj (\225\240 )Tj endobj Cholesterol (from the Ancient Greek chole-() and stereos (solid), followed by the chemical suffix-ol for an alcohol) is an organic molecule.It is a sterol (or modified steroid), a type of lipid. 489 0 obj <> (http://www.jbc.org/)Tj [369 0 R 370 0 R 371 0 R 372 0 R 373 0 R 374 0 R 375 0 R 376 0 R 377 0 R 378 0 R 379 0 R 380 0 R 381 0 R 382 0 R 383 0 R] endobj endobj endobj endobj 12 0 0 12 143.99991 509.99991 Tm endobj endobj endobj endobj 502 0 obj /T1_0 1 Tf endobj 499 0 obj endobj Contain 24 carbon atoms, 2 or 3 OH groups in steroid nucleus & a side chain ending in carboxyl group. <> 390 0 obj 2 0 obj endobj 500 0 obj 0 0 m well documented (7, 9, 19, 27, 32, 33), but the degradation of cholesterol by a member of the genus Gordonia was reported only recently (8). endobj <> F���L�&֖��|����nή� D�w�p�2�1ѥ�m:�ݤ�e��7A��&�>4L��x�a��:ǹ�=*�x3#�NJ�]%r%��c�?7��������6�u�Ij~�| Υu�;�]�H���Y>�Pq-1���'�z�,7λ5�<8�I{@�"F~�$C��ιo#S3���R�{[s�p z\��k��x����3"l�$�as�=����E`$Ȩ�7EՖ �6��W��>�/a�ĕ��KR� Degradation of EGFR through APMAP Siyuan Jiang1, Xuetong Wang1, Dalong Song2, XiaoJun Liu1,Yinmin Gu1, ... High cholesterol inhibits EGFR internalization by promoting the competitive binding of APMAP to EPS15R, which in turn activates ERK1/2 to promote epithelial-to-mesenchymal transition. BT [259 0 R 259 0 R 259 0 R 259 0 R 259 0 R 259 0 R 260 0 R 261 0 R 262 0 R 263 0 R 264 0 R 265 0 R 266 0 R 267 0 R] (DEGRADATION OF CHOLESTEROL)Tj 498 0 obj [424 0 R 425 0 R 426 0 R 427 0 R 428 0 R 429 0 R 430 0 R 234 0 R] <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> <> 472 0 obj With dialyzed preparations, it was possible to follow cholestenone for- mation from cholesterol by measuring the increase in absorption at 240 rnp in 90 per cent ethanol extracts. <> Normal cholesterol levels are strictly maintained by de novo synthesis and degradation and cells can sense their level of cholesterol through the membrane-bound sterol regulatory element-binding protein (SREBP) (Brown and Goldstein, 1997). HepG2 cells and HuH-7 cells both originated from a human hepatoma and endogenously express ABCA1. … <> /T1_0 1 Tf 0 g -7.55399 0 Td /T1_3 1 Tf 408 0 obj 465 0 obj endobj Get a printable copy (PDF file) of the complete article (2.5M), or click on a page image below to browse page by page. 491 0 obj <>stream <> (When this article is cited)Tj (alerts)Tj Cholesterol is an extremely important biological molecule that has roles in membrane structure as well as being a precursor for the synthesis of the steroid hormones, the bile acids, and vitamin D.Both dietary cholesterol, and that synthesized de novo, are transported through the circulation in lipoprotein particles. application/pdf L-a-distearoyl phosphatidylcholine; CH,cholesterol. -0.906 0 Td 472 0 obj (\240)Tj endobj )Tj <>/MediaBox[0 0 609.84 792.12]/Parent 534 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 21/Tabs/S/Type/Page>> 223 0 obj 0 1 TD endobj 485 0 obj endstream <> endobj /T1_3 1 Tf degradation of cholesterol 1. endobj endobj <> 1 0 obj endobj (http://www.jbc.org/content/206/2/511.citation.full.h)Tj 202 0 obj 494 0 obj (Alerts: )Tj 401 0 obj 205 0 obj Brown and C. … 452 0 obj ET Cholesterol and phytosterols can suffer oxidation under heating conditions to give Sterol Oxidation Products (SOPs), known by their toxic effects. <> -3.112 0 Td 535 0 obj BT <> Microsoft® Word 2010 <> Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH @article{Surdo2011MechanisticIF, title={Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH}, author={Paola Lo Surdo and Matthew J. Bottomley and A. Calzetta and Ethan C Settembre and A. 3.3.2. 0 g endobj 221 0 obj 514 DEGRADATION OF CHOLESTEROL diluted to 10 ml. 448 0 obj STABILITY AND DEGRADATION STUDIES OF CHOLESTEROL-LOWERING STATIN DRUGS MAŁGORZATA PIECHA DISSERTATION Mentor: Prof. dr. Polonca Trebše Nova Gorica, 2009 . [415 0 R 416 0 R 417 0 R 418 0 R 419 0 R 232 0 R] 150 0 obj FK�`�����I.4�3`>��nX�s�ƎQ&��"X.8�V'�?5���`d������"k�^z�&��[Z��0By ��Gc�HP9���AV[�qҲ�MN�gMC��7�����j�4o�|���+ �E� �����ug��!���G������~^���C:��� <> Sterol regulatory element-binding proteins (SREBPs) are transcription factors that control production of cholesterol and other lipids. uuid:a6809487-1dd1-11b2-0a00-530927bdd100 <> Chem.\240)Tj 0 0 1 rg 458 0 obj <> endobj Keywords: 7-dehydrocholesterol, cholesterol, DHCR7, degradation, vitamin D ABSTRACT . 2003-02-19T11:44:14+05:30 <> [438 0 R 439 0 R 440 0 R 441 0 R 442 0 R 236 0 R] 208 0 obj endobj thermal degradation of cholesterol were reduced greatly after incorporation of quercetin [17]. endobj 206 0 obj Free fulltext PDF articles from hundreds of disciplines, all in one place Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment (pdf) | Paperity endobj 4030 Thepublication costs of this article weredefrayed in part by page chargepayment. <> Cellular cholesterol levels are also modulated by a cycle of cholesterol esterification by acyl- CoA : cholesterol acyltransferase (ACAT) and hydrolysis of the cholesteryl esters, and by cholesterol metabolism to … 211 0 obj endobj endobj ( )Tj 502 0 obj endobj endobj Introduction to Cholesterol Metabolism. 459 0 obj -5.49997 0 Td BT endobj endobj endobj 201 0 obj -18.61797 0 Td When cholesterol levels are low, Scap escorts SREBPs from the ER to the Golgi where proteolytic cleavage releases the transcription factor … endobj endobj Cholesterol accelerated the proteasomal degradation of SM which required the N-terminal domain, partially conserved in vertebrates but not in lower organisms. 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